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Weaning Off Lexapro: How Hyperbolic Tapering Can Help

Weaning Off Lexapro: How Hyperbolic Tapering Can Help

This article explores risks and benefits of weaning off Lexapro, and why hyperbolic tapering may be the best approach to safe and successful discontinuation.

April 15, 2024
 min read
Outro Team
Written by
Bryan Shapiro, MD
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Antidepressants are commonly used to treat depression, anxiety, and other mental health disorders. However, many people have concerns about the long-term risks and side effects associated with these medications. Moreover, the process of tapering off antidepressants can be challenging, and patients may experience withdrawal symptoms.

One specific medication that patients may struggle with tapering is Lexapro (escitalopram), a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for anxiety and depression. In this blog post, we will discuss the risks and benefits of tapering off Lexapro, and why hyperbolic tapering may be the best approach for minimizing withdrawal symptoms and achieving successful discontinuation.

What Is Lexapro?

Lexapro (escitalopram) is a popular medication used to treat depression and anxiety. It is a selective serotonin reuptake inhibitor (SSRI) that blocks the reuptake (reabsorption) of serotonin into the neurons that release it. The U.S. Food and Drug Administration (FDA) approved Lexapro in 2002 and it has since become one of the most commonly prescribed antidepressants in the country.

Lexapro (escitalopram) and Celexa (citalopram) are both SSRIs widely used in the treatment of depression and anxiety. Escitalopram is the S-enantiomer of citalopram. In other words, citalopram is a mixture of two mirror-image molecules (S- and R-forms), while escitalopram is composed entirely of the S-form.

Reasons People Consider Weaning Off Lexapro

There are many reasons why people may want to stop taking their antidepressants, including concerns about long-term adverse effects, side effects, a desire to try non-drug methods for mental health, pregnancy, or a feeling that they don't need them anymore. If you are considering weaning off a medication like Lexapro, it is essential to discuss your decision with your doctor and develop a personalized discontinuation strategy that focuses on minimizing potential withdrawal symptoms while providing adequate support for your mental health.

Lexapro Side Effects

Like all antidepressant medications, Lexapro can cause certain side effects. In a clinical study involving 100 patients, looking at common SSRIs escitalopram, sertraline and fluoxetine, the prevalence of the most notable symptoms ranged from 38-64%.  Common side effects included flatulence, drowsiness, memory impairment, decreased concentration, yawning, fatigue, dry mouth, weight gain and light headedness. Patients on escitalopram notably experienced a higher incidence of headaches, pruritus (itching), memory impairment, decreased concentration, and dizziness.

Lexapro has been associated with a cardiovascular risk in QT prolongation, which is a specific, abnormal heart rhythm condition detectable via an electrocardiogram (ECG). While this side effect is relatively rare, it is a serious condition that could lead to life-threatening arrhythmias, such as Torsades de Pointes. The risk of QT prolongation is generally higher in patients with existing heart disease, older adults, and those with low levels of potassium and magnesium in their blood. Therefore, it's crucial for anyone starting treatment with Lexapro to have a comprehensive medical assessment to identify potential risk factors for QT prolongation. As always, the benefits and risks of any treatment should be thoroughly discussed with a healthcare provider.

Weaning Off Lexapro & Withdrawal Symptoms

All antidepressants can cause varying levels of withdrawal symptoms upon discontinuation, depending on the medication, duration of use, dosage, and individual factors. Among the SSRIs, Lexapro has a moderate risk of withdrawal, while other commonly prescribed medications, such as Paxil and Celexa, have a high risk of withdrawal. SNRIs, such as Effexor and Cymbalta, also have a high risk of withdrawal, while atypical antidepressants, such as Wellbutrin, have a low to moderate risk of withdrawal. These estimates are based on medication half-life as well as a collection of patient reports.

Withdrawal symptoms commonly occur upon discontinuation of antidepressants, including Lexapro. Symptoms can range from mild to severe and vary between patients. Common withdrawal symptoms include nausea, dizziness, headaches, and mood changes. It is important to understand the difference between acute and protracted antidepressant withdrawal, as the two come with an overlapping yet unique set of risks. To learn more about acute versus protracted antidepressant withdrawal, visit our blog post on the subject.

Linear Tapering vs. Hyperbolic Tapering

While weaning off antidepressants is approached in various ways, there are certain methods that are better (more evidence-based) than others. Linear tapering is the current standard of care, which involves reducing the medication dose in a linear fashion over a period of 1-4 weeks, depending on the starting dose. Unfortunately, linear tapering is not based on scientific evidence and can increase the risk of withdrawal symptoms and relapse.

Hyperbolic tapering, on the other hand, is a neurobiology-based method for deprescribing antidepressants, based on the hyperbolic relationship between antidepressant dose and brain activity. To produce a linear reduction of pharmacological effect, a hyperbolically decreasing pattern of dose reduction is required. Rather than decreasing the dose by fixed amounts, the dose should be decreased according to fixed intervals of biological effect. This means smaller and smaller dose reductions as one gets closer to zero. To learn more about the science behind hyperbolic tapering, check out its dedicated blog post.

Seeking Support From A Healthcare Professional

If you are considering tapering off Lexapro or any other antidepressant, it is recommended to seek professional help. Outro Health provides an evidence-based antidepressant tapering service that includes expert evaluations, personalized hyperbolic tapering plans, withdrawal symptom monitoring, and compounded medication prescriptions.

Outro Health's taper management program is conducted by a trained care team, including nurse practitioners and supervising psychiatrists. The clinical programs have been designed by a multidisciplinary team of experts, led by our Co-Founder, Dr. Mark Horowitz.


Tapering off antidepressants like Lexapro can be challenging, but it can be done safely and effectively with the right support and guidance. Hyperbolic tapering is an evidence-based method of discontinuing antidepressants that can minimize withdrawal symptoms and reduce the risk of relapse. Outro Health's taper management service provides personalized tapering plans and support from expert nurse practitioners to help patients successfully taper off antidepressants, while helping manage potential withdrawal symptoms and sustaining mental well-being.

If you are considering discontinuing Lexapro or any other antidepressant, speak with your doctor or consider an expert-led tapering program like Outro Health for safe and effective discontinuation.

The content provided in this blog, including all text and images, is for informational purposes only and not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment.

1. Horowitz et al., 2019. 2. Horwitz et al., 2022.

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