Getting off antidepressants isn’t easy, but we can help.

Evidence-based, personalized care from experts who get it.

Developed with experts from places like
WHY Outro?

We didn’t know it would be this hard, either.

When we're prescribed an antidepressant, we're rarely told the whole story—from the long-term side effects to how hard it is to stop them. Traditional discontinuation methods, most often rapid and linear, are not based on evidence and leave people feeling trapped on their medications, sometimes for life.

In a well-controlled study, only 6% of patients were able to get off, and stay off, their antidepressant at 12 months.
More than two-thirds of patients, most having trouble stopping previously, were able to come off their antidepressant via hyperbolic tapering.
What Is Outro?

Evidence-based methods, with compassionate care.

Outro is the first personalized, evidence-based solution for tapering off your antidepressant medications.

Evidence-based taper plans

Monthly appointments

Ongoing symptom monitoring

Compounded prescriptions

Holistic wellness library

"I was on antidepressants for 15 years and when I tried to come off them at the end of my Ph.D. (on how antidepressants work) I struggled with severe withdrawal symptoms — the most awful experience of my life.

I found there was a lack of support and knowledge from clinicians and researchers on how to safely stop antidepressants and manage withdrawal, which led me to co-found Outro."

Dr. Mark Horowitz


How It Works

Reduce your medication with confidence

Complete our intake process

Book a 15-minute enrollment call and complete your intake forms, so we can assess your needs and determine which of our services are appropriate for you.

Free evaluation

Schedule your free evaluation with an Outro care provider to review your medication and readiness to come off.

Build your tapering plan

Based on your review, work with your Outro provider to build a personalized tapering plan and complete any preparation required.

Taper off with expert support

With the ongoing support of your Outro provider, follow your personalized tapering plan and log any symptoms to stay on track.

The essentials

Our Services

Tapering, psychotherapy, or both—personalized for your stage of life.

Personalized Tapering

Personalized tapering plans and monthly subscriptions to equip you with the guidance, support, and tools you need to safely and sustainably reduce your medication.


Convenient video appointments with compassionate therapists trained specifically in pre-taper resourcing, withdrawal support, and relapse prevention.

Here’s to taking the first step

Get started with a free evaluation.


Common questions about antidepressants, tapering and Outro's services.

Who is Outro for?

Outro is for people 18 years and older who are currently taking an antidepressant medication and thinking about decreasing or stopping the medication altogether. Outro’s services are currently not available for people in certain situations or with certain conditions. These include (but are not limited to) people who:

  • Have active and serious substance abuse issues
  • Have been diagnosed with dementia
  • Have been diagnosed with schizophrenia or schizoaffective disorder
  • Have been hospitalized for bipolar disorder in the past
  • Have attempted to end their life in the past 12 months
  • Are actively suicidal or in crisis

To see if you are a candidate for Outro’s services, click “Get Started”.

If you are in a life-threatening situation, call 911 or the National Suicide Prevention Line at +1-833-456-4566, or go to the nearest emergency room.

How is Outro different from working with another provider?

Safe antidepressant deprescribing requires a comprehensive approach that is often difficult for an individual prescriber to provide, due to the time required. It also requires up-to-date knowledge on the latest techniques in tapering antidepressants that are not yet widely taught in North America. Think of Outro as a specialist in tapering.

At Outro, we walk with you every step of the way. Our specialized, high-touch care team takes time to get to know you and your goals, and provides an advanced, individualized approach to tapering off antidepressants informed by the latest guidance and clinical evidence. Through Outro’s app, your symptoms and progress are continuously monitored by your Provider, who can reach out to offer coping strategies or adapt your care plan accordingly. If you have questions or concerns that arise in between appointments, your Outro provider is available via 1-to-1 chat.

Why shouldn't I just stop my antidepressants?

Going cold turkey (stopping in one day) is not a good idea! Why? Because the quicker you stop your antidepressant the more severe your withdrawal symptoms are likely to be, and the higher the likelihood that you’ll need to go back on your medication.

Sometimes these symptoms can be so unpleasant that they interfere with your ability to work or carry on normal social activities. Sometimes severe withdrawal symptoms can be very disruptive or even lead to hospitalization.

Tapering (stopping slowly in small steps) is therefore highly recommended to minimize the risks of these issues.

What is hyperbolic tapering?

Hyperbolic tapering (sometimes called the Horowitz-Taylor method)1 is based on the fact that as antidepressant dose goes up, drug action on brain cells increases, but not in equal steps, higher dosages having less and less additional influence – a decreasing return on investment. The graph showing this is called a hyperbolic curve (goes up faster at low doses and flatter at higher doses).

Tapering based on this method gradually backs you out of the drug with reductions following this natural curve, with the size of dose reduction getting smaller as the dosage gets lower. As very low doses (e.g. 1 or 2mg) have much larger effects than people expect, many people need to taper down to very small doses before stopping so that the final ‘jump’ to zero is not too large a shock to the nervous system.

These very low doses are difficult to make up with commonly available tablets, so Outro recommends compounding pharmacies to make these options available.

1. Horowitz MA, Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. The Lancet Psychiatry. 2019;6(6):538-546.

What is virtual care?

Virtual care, also referred to as telemedicine or telehealth, is a modern healthcare delivery method that allows patients to access medical services remotely via digital technology.

In the context of our services, virtual care is used to provide convenient, secure, and private access to Outro clinicians. You can communicate with an Outro provider from the comfort of your home, or wherever you might be. All of these services are designed to be easily accessed via your digital device, be it a smartphone, tablet, or computer.

Do I need a referral from my primary care provider?

You do not need a referral from your primary doctor or healthcare provider to work with Outro. However, with your permission we may reach out to your primary care provider for more information on your medical history, or to keep your primary doctor informed of your medical progress if you decide to subscribe to Outro.

Is Taper Management covered by public or private insurance?

Outro’s Taper Management is not currently covered by provincial nor private health insurance. We're actively working to build the evidence base and partnerships required to ensure that safe, evidence-based deprescribing is recognized as an integral part of healthcare.